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Under physiological conditions, Nrf2 binds to Keap1 located in the cytoplasm to form a dimer, but after oxidative stress occurs, Keap1 undergoes conformational changes due to electrophilic or oxidative signal modification, thereby releasing Nrf2 into the cell nucleus (Liu et al., 2022b)

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The serum concentration of magnesium is regulated by establishing a balance between intestinal absorption, renal excretion, and bone buffer

doi: 10.3389/fmicb.2022.1111930

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However, how inflammation drives hematopoietic aging and the mechanisms through which the two phenomena are linked remain understudied