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The best-known mechanisms include inhibitory phosphorylation of the E1 subunit of PDHC and BCKDC, which is controlled by specific kinases and phosphatases 4

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PMID: 16034940

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Although both modes used a 0.1% formic-acid aqueous/organic systemwhich is known to favor cationization and may reduce sensitivity for some anionic species in ESI()our conclusions are supported by statistics performed separately within each polarity and are concordant with orthogonal readouts of ferroptosis, including dose-dependent increases in ROS, Fe and MDA, GSH depletion, and ultrastructural changes on TEM