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The classification of folates depends on the oxidation state of the pterin and carbon unit, as well as the polyglutamylation state

doi: 10.1124/dmd.110.032813

The following experimental evidence supports the hypothesis: (i) asparagine and serine concentrations in cancer cells are higher than in normal ones (Bi and Henry, Figure 6 Glutamine and ROS scavenging Besides energy production, glutamine is also involved in regulation of ROS scavenging that represents another cross road for cancer cells that are under ROS stress and enhanced glutathione (Glutamate-Glycine-Cysteine-GSH) synthesis (Newsholme et al., 2003