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Description

Mcl-1 and Bcl-xL are essential for survival of the developing nervous system

Kroemer G, Levine B

Kharat SS, Ding X, Swaminathan D, Suresh A, Singh M, Sengodan SK, et al

10.3233/RNN-211249 Restor

Journal of medicinal chemistry 54 , 13911400 (2011)

In addition, the small leucine-rich repeat proteoglycan of bone extracellular matrix tissue biglycan, which is correlated with an aggressive phenotype of osteosarcoma, supported tumor growth and induced resistance to chemotherapy drug doxorubicin by forming a complex with IGF-1R leading to activation of the IGF-1R signaling pathway in human osteosarcoma cell line MG63 (37)