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Diagnosis of HPII can be made based on plasma proline levels, as well as elevated urinary P5C levels, proline, hydroxyproline, and glycine, which serve as important markers

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A 30-min permeability test for SF and EBA markers performed after the 24-h nanocarrier permeability assays confirmed that the integrity of the BBB models was preserved and the nanocarriers had no barrier damaging effect (Table S2)