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Methods: Two randomized, double-blind (DB), active-controlled trials to evaluate TAF treatment of hepatitis e antigen (HBeAg)-negative (Study GS-US-320-0108) and HBeAg-positive (Study GS-US-320-0110) participants with CHB were conducted over 8 years (384 weeks)

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A breach results in the release of apoptotic molecules, such as cytochrome c (CYCS), apoptosis-inducing factor mitochondria-associated 1 (AIFM1), and diablo IAP-binding mitochondrial protein (DIABLO/SMAC) [112]