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These results may suggest that the tissue changes associated with AGE accumulation could be driven by alterations to fiber deformation mechanisms, such as fiber-fiber sliding

doi: 10.1084/jem.20020407 60 ComanducciM.BambiniS.CaugantD

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Potential Side Effects and Limited Human Data While preclinical studies have not shown significant toxicity at standard doses, the research in humans is still in its early stages

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