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4 CS is a condition where increased pressure in a muscle compartment leads to reduced blood supply and function, which can cause functional deterioration after 12 to 24 hours of total ischemia

Nutritional Deficiencies: Inadequate levels of specific nutrients such as vitamin B12 and iron disturb the biochemical pathways that regulate melanin distribution

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Vitamin B12 is an essential nutrient that supports red blood cell formation, neurological function, and DNA synthesis