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These include enzymes of energy metabolism (phosphofructokinase, glyceraldehyde-3-phosphate dehydrogenase, -ketoglutarate dehydrogenase, and I complex of respiratory enzymes), enzymes of signaling cascades (protein kinase A, protein kinase C, protein tyrosine phosphatase 1b, and protein phosphatase 2A), transcription factors (NF-B, HIF1, and AP1), and many others

JAMA 311 , 3344 (2014)

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Testing: After a 2-week introductory period, baseline blood and urine samples were obtained 2.5 hours after ingestion of the standard meal

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