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Moreover, the GSH-to-GSSG ratio that was maintained close to control levels when worms fed with empty vector were grown in the presence of GA, glycine, or serine (Fig

Arch Biochem Biophys 145(1):2734 Stell JG, Wheelhouse RT, Wright CW (2012) Metabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase

This results in excessive glucocorticoids release, dysregulation of the negative feedback system, receptor resistance, and the release of pro-inflammatory cytokines