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( F H ) Carnitine concentrations in plasma ( F ) or urine ( G ) and carnitine-excreted fraction ( H ) in Ctrl and cKOt mice before DOX treatment (baseline), 3 or 7 days after the beginning of the DOX treatment (3d or 7d DOX), and 2 weeks after the end of DOX treatment (14d post-DOX)

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The association between importin and Ran-GTP comprises 10 salt bridges and 11 hydrogen bonds, burying 2388 2 of the importin concave surface

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Such supernatant was subsequently followed by centrifugation (11,000 g for another 15 min) and filtration (1.0, 0.45, and 0.22 m in order) to remove impurities larger than 0.22 m [32]