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This allows it to reach tissues that wouldnt normally get much ALA which may explain why higher supplemental doses (like 600mg) can affect nerve health, blood sugar, and oxidative stress in ways your bodys natural supply cant.12 Once you take ALA as a supplement, several factors affect how well your body absorbs and uses it

To avoid these limitations, targeted activation of the endogenous cellular antioxidant machinery has emerged as an alternative therapeutic strategy for the reduction of oxidative stress (Davis and Pennypacker 2017

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