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The presence of adequate circulating T 4 and T 3 feeds back at the level of both the hypothalamus and pituitary, decreasing TRH and TSH production ( Figure 2 )

Curiously, pre-treating immune cells with caffeine and subsequently transplanting them into mice subjected to social defeat stress also produced antidepressant and anti-inflammatory effects, and an increase in hippocampal neurogenesis, suggesting a substantial and positive association between caffeine and related processes [40]

2 In terms of morbidity, UC can significantly impact patients lives, causing a range of symptoms including abdominal pain, diarrhea, rectal bleeding, fatigue, and weight loss

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3C), indicating a good agreement between mass spectrometry and ELISA measures, particularly regarding sibling pair differences