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Nowadays, it is well accepted that in responding to environmental cues the embryo demonstrates a high degree of developmental plasticity, modulating its metabolism, gene expression and phenotype 4

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In order to activate the carboxyl group of 4-MBA for better connection with IL-6 antibody (IL-6Ab), we used (1 (3-dimethylamino-propyl)-3-ethylcarbon diimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) to play this role