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Rather than providing glutathione directly, NAC serves as a precursor that supplies cysteinethe rate-limiting amino acid in glutathione synthesis

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Similar to SR-BI, SR-BII is also an HDL receptor, but its expression levels are lower, hence, SR-BII is less efficient than SR-BI in reducing the level of plasma HDL (77,78)

Fourth, NAC nebulization three times daily for 12 weeks may not be easy in real clinical practice