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In particular, increasing evidence highlights the pivotal role of innate immune activation in initiating and amplifying the adaptive immune response, particularly the activation of autoreactive CD8 + T cells, which are the ultimate effectors of melanocyte destruction

At baseline, approximately 80% of patients had the IFN signature of gene expression at baseline, and tended to have better responses

Dnm2 : Dynamin 2 (Dnm2) is a large GTPase mainly involved in membrane trafficking through its function in the formation and release of nascent vesicles from biological membranes

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