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Our study also found that NRF2, GPX4 and SOD1 expression levels were higher in the neoadjuvant chemotherapy-resistant group compared to the sensitive group, further supporting our hypothesis and demonstrating the adverse effects of GSH on chemotherapy in breast cancer patients

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Inhibition of ferroptosis by ferrostatin-1 (Fer-1) was shown to reduce infarct size, improve left ventricular (LV) systolic function, and attenuate LV remodeling in myocardial IRI via lowering the levels of pro-ferroptotic LPO and reducing cardiomyocyte cell death, providing evidence that ferroptosis regulates cardiomyocyte cell death in the context of MI [89]

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This rapid increase in intracellular Ca2+ concentration is the primary signal for the exocytosis of vesicles containing pre-synthesized GH