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3510-C ALCOHOL MODULATES HEPATIC AMYLOID ETA AND LIPID METABOLISM IN APP/PS1 MOUSE MODEL OF ALZHEIMERS DISEASE Veronika Brezani, Radhika Joshi, Marti Ortega-Ribera, Mrigya Babuta, Yanbo Wang and Gyongyi Szabo, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA Background : Chronic alcohol abuse impairs liver function and increases the risk of dementia

Recently, it was also found that plant extracts can regulate microglia to express the M2 phenotype more than the M1 phenotype (Yang et al., 2017) to reduce neuroinflammation and nerve cell damage and to clear A (Figure 2)

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