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Pharmacokinetic and pharmacodynamic study of amodiaquine and its two metabolites after a single oral dose in human volunteers

American Journal of Psychiatry, 164(6), 942-948

The general mechanism of action of combined hormonal contraceptives (estrogens + progestogens) is based on the negative feedback that estrogens induce on the hypothalamus, inhibiting the secretion of gonadotropin release stimulating hormone (GnRH) and, consequently, preventing the increase in the secretion of gonadotrophins by the pituitary to stimulate ovulation in the middle of the cycle

Were looking at half a gram per pound up to just under a gram a pound, gram per kilo, up to about two grams per kilo, like fairly standard stuff

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