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doi: 10.1016/j.neulet.2020.135464 345 SorensonJ

This enhanced microvascular integrity fundamentally alters the local biological environment, ensuring an exponentially higher delivery rate of oxygen, growth factors, and critical nutrients to tissues that are notoriously avascular or poorly vascularized, such as dense tendons, ligaments, and deep cartilage matrices, thereby dramatically accelerating their biological repair timelines

The hormone promotes gluconeogenesis (glucose production) in the liver and reduces glucose uptake in peripheral tissues, creating an insulin-resistant state

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The presence of anti-GFAP antibodies in serum and cerebrospinal fluid is a critical diagnostic criterion, as clinical manifestations are nonspecific and can include movement disturbances, paresthesia, visual impairment, brainstem syndrome and autonomic dysfunction 259,260,261,262

Tra i pathway coinvolti figurano: vie di segnalazione dell'infiammazione (riduzione TNF-alpha, IL-6), sistemi di risposta al danno ossidativo (up-regulation degli enzimi antiossidanti), fattori di crescita (TGF-beta, FGF) e pathway di controllo del ciclo cellulare