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Previous studies have emphasized the importance of epigenetic changes, such as DNA methylation, histone modifications and chromatin remodeling, in the development of endometriosis (107109)

The oral diabetes medication canagliflozin (Invokana) is also based on this mechanism (Sarnoski-Brocavich 2013

Santos Rocha C, Gomes-Santos AC, Garcias Moreira T et al (2014) Local and systemic immune mechanisms underlying the anti-colitis effects of the dairy bacterium Lactobacillus delbrueckii

Folate-sodium alginate-cholesterol nanoparticles delivering doxorubicin and metformin achieved targeted accumulation and induced various forms of programmed cell death, including necroptosis, apoptosis, and pyroptosis in xenograft melanoma tumors (Song et al., 2021)