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Despite its importance, many people suffer from vitamin D deficiency symptoms, such as chronic fatigue, muscle weakness, and a compromised immune system

First hints towards this idea came from genome-wide association studies mapping IBD genetic risk loci to mitochondrial function-associated genes 26,27,28 , implying mitochondrial disturbances as underlying mechanism in IBD pathogenesis

In IPF patients, interestingly, GPX3 levels were significantly increased in total lung homogenate, but consistently low in BALF

Furthermore, Dussiot revealed that the RAP-536 and RAP-011, ligands for activin receptor IIa, exhibit potential in ameliorating, IE in a mouse model of -thal (Suragani et al., 2014a)

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Human hepatoma cells (HepG2) are widely used as an in vitro model to study the effects of several xenobiotics in hepatocytes [37, 38]