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Instead, research points to the interaction of low MAO-A and childhood neglect or mistreatment in males, increasing the relative risk of aggression.[ref] Really rare mutations that significantly decrease MAOA levels in humans cause a genetic disease called Brunner syndrome, and the symptoms include impulsive and antisocial behavior.[ref] So the effect of low MAOA on impulsivity is real, but it isnt necessarily caused by the common variants that decrease MAOA in all individuals

doi: 10.1111/jcmm.17818 250 YangSZhuYShiYSuSLiangHLiSet al

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Uehara Y, Fukazawa H, Murakami Y

60 , 1037 (2013) Zhang, Q., Ames, J.M., Smith, R.D., Baynes, J.W., Metz, T.O.: A perspective on the Maillard reaction and the analysis of protein glycation by mass spectrometry: Probing the pathogenesis of chronic disease

its trials co-escalated to a target of cagrilintide 2.4 mg plus semaglutide 2.4 mg once weekly