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however, while these studies did investigate the function, they did not explicitly examine the cell-to-cell association which becomes possible with in vitro models or provide detailed explanations in line with the in vivo findings

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5.3 Bullous and Exfoliative Skin Toxicity Serious and sometimes fatal, bullous, blistering and exfoliative skin toxicity, including cases suggestive of Stevens-Johnson Syndrome/Toxic epidermal necrolysis can occur with pemetrexed