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Z Vergl Physiol 48:181189

doi: 10.1186/s12935-022-02777-7 119 ScheauCet al

The loss of induction of the -glutamyl cysteine synthase-light subunit (GCS-LS) is considered to be the responsible factor for loss of liver GSH level even under ethanol treatment [70]

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These anomalies were associated with significant increases in 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), and iron in the midbrain of the A53T mice (Figure 1, DF)