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However, due to age-related immunosenescence and the capability of senescent cells to evade immune surveillance, senescent cells are spared and accumulate in diverse tissues (75)

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This inhibits NRF2 from dissociating from Keap1, impairing its ability to activate antioxidant defense mechanisms ( Figure 2 )

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Research on KPV delivery using iontophoresis and microneedles demonstrated improved transdermal delivery across human skin