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Trotti D, Peng JB, Dunlop J, Hediger MA

A recent paper suggests that Mt-Keima mice are a more sensitive detector of parkin-dependent mitophagy than MitoQC, which they attribute to the fluorescent probe in MitoQC localized on the outer mitochondrial membrane where it may be subject to proteolytic cleavage outside of the lysosome (Liu et al., 2021)