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Sappanone A similarly combats inflammation and ECM degradation in OA by attenuating chondrocyte ferroptosis through the SIRT1/Nrf2 pathway (165)

The only serious concern was that glutathione has a relatively short half-life in the bloodstream, which could potentially limit the duration of its efficacy

To assess drug release, we applied FITC-conjugated D-CuP hydrogel to the wounds and measured the fluorescence signal of the residual hydrogel at predetermined time intervals in darkness

In the cardiovascular system, succinate released by macrophages stimulated the production of inflammatory cytokine IL-1 by activating HIF-1, thus inducing endothelial inflammation and then promoting atherosclerosis