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HAAO has an important role in supplying a precursor for de novo NAD biosynthesis and acts as a tumor suppressor to block 3-HA-mediated ferroptosis inhibition 65,66

EETs are known to increase under oxidative stress conditions and have been associated with anti-inflammatory activity [51,52,53]

These studies were conducted by a single research laboratory and, for many years, lacked independent replication outside that group

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