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Moreover, it has been suggested that starvation reduces liver glycogen storage and hence reduces UGT conjugative ability leading to a greater fraction of the dose being oxidised to NAPQI [77]

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About 5-10% of patients require adjusted dosing due to poor response, often from concurrent deficiencies or misdiagnosis

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10.1371/journal.pbio.2006203 37 FillebeenC.CharleboisE.WagnerJ.KatsarouA.MuiJ.ValiH.et al (2019)