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However, several histological abnormalities were found in these mice, abnormalities that spanned several tissues and included chronic inflammation and hyperplasia of the gastric epithelium, calcification in the brain, testicular atrophy, loss of cytoplasmic granules in the striated duct cells of the salivary gland, and thinning of compact bone

Yasuda S, Liang MH, Marinova Z et al (2009) The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons

The latter is chemically unstable due to the reactive carbon of the isothiocyanate group (N=C=S) that easily reacts with nucleophiles such as thiols

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The GST P1-1 enzymatic reaction is represented in Fig 2