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doi: 10.3390/antiox10091442 16 HouTYWuSBKauHCTsaiCC

10.3389/fmicb.2021.587035 22 BenesJ.ViechovaJ.KabelkovaM.HorovaB

The most common food-related cause is vitamin-fortified products or energy drinks

Health experts have cautioned against use of the drugs, citing a lack of clinical trials for humans and the unknown long-term effects of the substances

626 The absence of ALOX5 expression eliminates HTTQ94-induced ferroptosis under oxidative stress conditions, suggesting that ALOX5 is essential for ferroptosis mediated by mutant huntingtin and could be a promising new target for HD treatment

Beyond its established roles in autoimmune disorders, neurodegeneration, and cancer, ferroptosis exhibits distinct organ-specific features in the kidney, where its activation is tightly linked to the disruption of renal iron homeostasis, lipid metabolism, and antioxidant defense systems (278, 279)