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Independent replication, off-target profiling, and assessment in sorafenib-resistant and normal hepatocytes are needed before translational conclusions

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These approaches have been used to trap reactive sulfur directly 33,37

422 , 423 Overall, this highlights the core role of microorganisms in driving metabolic enzyme dysfunction and protein homeostasis imbalance

A Role for NHR Signaling and Fatty Acid Desaturases in Aging Adding to the role for DAF-12 in longevity, a new study reports a key role for another NHR and for one downstream target, a fatty acid desaturase (Goudeau et al., 2011)