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10.1038/npp.2016.96 74 LiQ.BarresB

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EMBO J 22: 19811989 Le Gall S, Neuhof A, Rapoport T (2004) The endoplasmic reticulum membrane is permeable to small molecules

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In preclinical studies of breast cancer cell lines, inhibition of PAR-1 resulted in a significant reduction in tumor growth and metastatic lesions [135137] (Figure 4)

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Yet, conversations around PCOS, metformin, and hair loss have been increasing, raising questions about whether this trusted medication has hidden side effects

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Castagn V, Rougemont M, Cunod M, Do KQ

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Systemic adverse reactions are unlikely from topical administration

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