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PLoS One 7(3):e33264 Russell ST, Tisdale MJ (2011) Studies on the antiobesity effect of zinc-2-glycoprotein in the ob/ob mouse

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These findings suggest that certain cytokines might exert positive or negative effects on different tissues, suggesting that tissue-specific targeted therapy is an essential strategy to protect other normal tissues, such as the ovary, from NRTP-induced damage

doi: 10.1016/j.freeradbiomed.2013.01.024

Some users follow a cycle (3 months on, 1 month off) to let the body reset and avoid dependency