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While chronic inflammation in SS does not inevitably result in fibrosis, once this morphological change has occurred, it is irreversible

Safety has been manageable so far, and randomized/combination cohorts (e.g., with 5-FU/leucovorin/bevacizumab) are underway

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Collectively, these enzymes coordinate autophagy across physiological and disease states (Fig

A similar mechanistic study on ultraviolet-damaged skin cells found that 5 uM of sulforaphane induced the expression of Nrf2 target genes including NQO1 at 1.5 times the normal rate, which led to a significant reduction of sunburn damage in the cells

However, the identity of these cells in the salivary gland, whether they are capable of regenerating the tissue, and the mechanisms by which they are regulated are unknown