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Although the MISEV guidelines have improved transparency and rigor in EV reporting, they primarily address minimal reporting standards and do not yet resolve critical issues related to inter- and intra-batch heterogeneity, potency assessment, or clinical-grade validation (MISEV guidelines

Metabolomic profiles were correlated with treatment response, defined as 50% reduction from baseline HRSD 17 scores

Enzymatic antioxidants are localized in specific subcellular compartments where radicals are frequently generated (mitochondria, peroxisomes or microbodies, cell cytosol) or are present in the systemic circulation

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis

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