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Metabolomic analyses of reactive astrocytes in mouse models have revealed that late-stage AD is associated with synaptic dysfunction and neurotransmitter imbalances, primarily due to impaired glutamine synthesis 71

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The loss of function or alteration in reactive astrocytes not only affects the ion buffering system but also equally affects the neurotransmitter signaling cascade in the animal model of HD (Tong et al., 2014)

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Purine catabolism is an underappreciated, but important component of the homeostatic response of mitochondria to oxidant stress

Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, et al