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Description

The ability of ESA to enhance the kinetics of cell death when GPX4 is maximally inhibited shows that ESA and GPX4 inhibitors trigger ferroptosis by distinct mechanisms

OgataKSasakiAKatoYTakedaAWakabayashiMSarentonglagaBet al

We'll set the stage

Int J Radiat Oncol Biol Phys (2015) 92(3):6138

& Quayle, D

Studies have shown that in the absence of GPX4, the calcium-independent phospholipase iPLA2 acts as a major ferroptosis suppressor in a GPX4-independent manner (Chen et al