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Clinical Pharmacokinetics, 46 (4), 281-290

In PD, aggregated syn, particularly in its protofibrillar form, impairs proteasome activity, reducing its efficiency in processing both ubiquitinated and nonubiquitinated substrates [166, 167, 168]

Another study done by Kankofer et al published in the journal Aging clinical and experimental research that in younger years, ovaries have higher intracellular glutathione (GSH) levels

Liu et al., 2025)

These effects occur partly through estrogen receptor activity in the hypothalamus and partly through alterations in lipid metabolism