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second, the tag-analyte conjugate should have a relative high molecular weight to avoid interference by matrices in the low molecular area

For example, interleukin-1 drives cartilage degradation via MAPK signaling, activates NF-B, suppresses type II collagen (Col II) expression, and increases the synthesis and secretion of interleukin-6 and tumor necrosis factor- (Wang et al., 2020

Cereblon encodes a 442 amino acid protein, with a molecular weight of 51 kDa, which is widely expressed in all tissues 4,37,38

However, most toxins do not naturally have a reactive site that enables them to bind to a conjugation molecule

Semin Immunopathol (2017) 39:52939

Nausea or Upset Stomach: Some people may experience gastrointestinal discomfort, such as nausea, vomiting, or diarrhea, although these side effects are rare