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Methods: Six- to eight-week-old male and female Liver FXR knockout (( Fxr floxed/floxed , albumin Cre (+), Fxr LKO) and control (Cre-) mice were fed either a low-fat control diet or a NASH Fast Food (FF) diet (Western diet with 21% milk fat, 1.25% cholesterol, and 34% sucrose) both supplemented with 0.1% (w/w) UDCA for 16 weeks