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Interestingly, as it occurs along the crypt-villus axis in the intestinal tissue, in Caco-2 cells, active p-ERK1/2 is mainly expressed in undifferentiated cultures, while its activity decreases when Caco-2 cells differentiate upon confluency (Aliaga et al

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Cells were transplanted around cervical spinal cord respiratory motor neuron pools, the loss of which results in respiratory failure and death in ALS, and transplanted GRPs showed robust survival up to 3 months post-transplantation