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Similar to what is observed in monocytes and macrophages, G6PD-d may limit the production of NADPH-dependent ROS that act as second messengers to enhance NFAT, AP-1, and NFB signaling 89,116,117

10.1042/bj3490787 Biochem

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It replenishes hepatic glutathione levels, therefore preventing or treating acetaminophen toxicity (more on this here)

TLR-HEK-cells were seeded on 12 well TPP plate until the cell confluency reached up to 7080%

Due to the direct binding of Asn35 to EA, the IC 50 value of N35D was 10-fold greater than that of WT, whereas the IC 50 values of N35A and N35Q were 70- and 160-fold greater than those of WT (Table 1), indicating that the structural specificity of the side-chain of Asn35 is crucial for EA binding