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Indeed, MetS, prevalent among obese individuals, often manifests with glucose intolerance, insulin resistance and dyslipidemia (i.e., hypertriglyceridemia and hypercholesterolemia) (Cornier et al., 2008)

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doi: 10.1093/biolre/ioad017 93 SrensenAEWissingMLSalSEnglundALDalgaardLT

doi: 10.1016/j.nbd.2011.01.021

Of note, Trx2 is localized to the mitochondria and has been found to play an important role in limiting mitochondrial ROS production and regulating cardiac function 10,11