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FEBS J 288(22):64926509 Editor information Editors and Affiliations Rights and permissions Copyright information 2023 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature About this protocol Cite this protocol Gnanasekaran, P., Pappu, H.R

However, this is not its primary or intended mechanism of action

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Thus, it is important to properly control the expression level of proinflammatory cytokines upon exposure to harmful stimulants

Among them, HLA alleles, especially the HLA-DR1 and HLA-DR4 loci, play an important role in the development of RA by mechanisms that may be related to the formation of citrullinated antigens and immune tolerance of CD4 + T cells (Wysocki et al., 2020