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Additionally, it was shown that P53, a significant gene in tumor suppression, has the ability to reduce SLC7A11 expression to inhibit cystine uptake by system x c , thereby impairing the activity of GPX4 and leading to decreased antioxidant capacity, ROS accumulation, and ferroptosis (47)

Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3

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Upregulation of the activity of Nrf2 and, subsequently, the antioxidant enzymes, could prevent the onset of DR complications in diabetic patients

Evidence suggests that isoflavones may inhibit testosterone-mediated prostate cell growth (Kumar 2004)