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Meta-analyses of stimulant use, as it relates to the dopaminergic system, indicate that cocaine leads to higher striatal DAT availability and lower D2/D3 receptor availability (Ashok et al., 2017

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Excitotoxicity is discussed to be involved in stroke, traumatic brain injury as well as neurodegenerative diseases such as multiple sclerosis, Alzheimers disease, amyotrophic lateral sclerosis (ALS), Parkinsons disease, Huntingtons disease, and multiple sclerosis

2024 Mar;24(2):100030

In the CNS, it is well recognized that an immense diversity of neurons alongside glial cell populations, with both lineages exhibiting significant cellular heterogeneity (Siletti et al., 2023