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Taken together, these results demonstrate that the Nrf2 gene is directly regulated by the core clock via conserved E-box element in its promoter and also that Nrf2 transcriptionally regulates BMAL1 and CRY2 expression, thereby establishing a feedback loop and providing a possible molecular mechanism by which oxidative signals might input into the circadian clock

Animal experiments showed that iron content was increased in the kidney tissue of streptozotocin (STZ)-induced DKD mice and diabetic (db/db) DKD mice, especially in the renal tubules

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Management of endocrine disease: GH therapy and cancer risk in hypopituitarism: what we know from human studies

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Kujawska et al., 2017)