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If the smell is caused by TMA produced from L-carnitine, pausing the supplement usually reduces the odor within several days

In chronic pain and depression, chronic exposure to stress is a common factor that may produce long-lasting changes (i.e., maladaptive neuroplasticity) in highly sensitive brain areas such as the prefrontal cortex and the hippocampus and in their functional connections, which may underlie the cognitive and behavioral impairments accompanying these conditions (Teffer and Semendeferi, 2012

Therefore, more studies are needed to confirm the role and specific mechanisms of TMAO in MAFLD

[1] The shuttle is regulated at the CPT-I level, being inhibited by malonyl-CoA from beta oxidation, preventing a futile cycle

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